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Contraindications
Hypersensitivity, uncontrolled hypertension.
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Special Precautions
Pregnancy and lactation, children. Hypertension; history of seizures; hepatic impairment; sickle cell anaemia; sudden stabing migraine-like pain (warning sign of hypotensive crisis); exclude other causes of anaemia; ischaemic vascular disease; thrombocytosis; epilepsy; malignant disease; increase in heparin dose may be needed; increased risk of thrombosis when used for anaemia before orthopedic surgery; CV disease including recent MI/cerebrovascular accident. Monitor haemoglobin, BP and electrolytes; platelet count for 1st 8 wk.
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Adverse Reactions
Hypertension, hypotension, chest pain, fatigue, fever, headache, dizziness, GI effects; myalgia, arthralgia, limb pain; skin reactions; shunt reactions, hyperkalaemia; dyspnea, cough, bronchitis; infection; transient increase in platelet count; influenza-like symptoms; peripheral oedema; Inj site pain.
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Drug Interactions
Antagonism of hypotensive effect and increased risk of hyperkalemia with ACE inhibitors and angiotensin II receptor antagonists. Ethanol.
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CIMS Class
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ATC Classification
B03XA02 - darbepoetin alfa ; Belongs to the class of other antianemic preparations.
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